miRDB: An online database for prediction of functional microRNA targets

MicroRNAs (miRNAs) are small noncoding RNAs that act as master regulators in many biological processes. miRNAs function mainly by downregulating the expression of their gene targets. Thus, accurate prediction of miRNA targets is critical for characterization of miRNA functions. To this end, we have developed an online database, miRDB, for miRNA target prediction and functional annotations. Recently, we have performed major updates for miRDB. Specifically, by employing an improved algorithm for miRNA target prediction, we now present updated transcriptome-wide target prediction data in miRDB, including 3.5 million predicted targets regulated by 7000 miRNAs in five species. Further, we have implemented the new prediction algorithm into a web server, allowing custom target prediction with user-provided sequences. Another new database feature is the prediction of cell-specific miRNA targets. miRDB now hosts the expression profiles of over 1000 cell lines and presents target prediction data that are tailored for specific cell models. At last, a new web query interface has been added to miRDB for prediction of miRNA functions by integrative analysis of target prediction and Gene Ontology data. All data in miRDB are freely accessible at http://mirdb.org

Multi-Image Semantic Matching by Mining Consistent Features

This work proposes a multi-image matching method to estimate semantic correspondences across multiple images. In contrast to the previous methods that optimize all pairwise correspondences, the proposed method identifies and matches only a sparse set of reliable features in the image collection. In this way, the proposed method is able to prune nonrepeatable features and also highly scalable to handle thousands of images. We additionally propose a low-rank constraint to ensure the geometric consistency of feature correspondences over the whole image collection. Besides the competitive performance on multi-graph matching and semantic flow benchmarks, we also demonstrate the applicability of the proposed method for reconstructing object-class models and discovering object-class landmarks from images without using any annotation.Comment: CVPR 201